For particle size distribution measurement of Domperidone API, both wet and dry dispersion methods could provide high precision results. However, since Domperidone API is fragile, adequate data support is required for sample dispersion, especially for dry dispersion method.
In this application note, compared with dry dispersion, wet dispersion was observed to provide data with better repeatability, correlation, and rationality. Therefore, wet dispersion method is relatively reasonable to analyze particle size distribution of Domperidone API.
Measurement by technology: