The Importance of Evaluating Reproducibility

For particle sizing instruments, the evaluation of reproducibility is important in several aspects:

(1) to understand the long-term stability of the instrument;

(2) to evaluate the stability of the sampling method;

(3) to assess the standardization degree of the operation procedure;

(4) to assess the consistency of the instrument setting parameters;

(5) to evaluate the effects of the environment on the instrument.


Standard samples (or reference materials) should be used for the evaluation of reproducibility. The standard samples can be standard powders with certificates, the samples received with the instrument, or the verified and qualified samples kept by users. It does not matter which standard sample is used. However, it is important to ensure the quality of the standard sample is stable and has not changed. The reproducibility should be evaluated every three months and the result should be compared with the previously evaluated results. If the reproducibility error is within the required range, it indicated that there are no changes to the instrument, sampling, operation, parameters, and environment, and the test results are objective and valid. If the reproducibility error exceeds the required range, the causes must be found and addressed.

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